Complementary and alternative medicine research presents unique problems for research ethics committees which must be considered in some detail. Applying conventional research techniques to CAM raises a number of issues which ethics committees may find challenging. CAM is widely available and this will have a substantial effect on any proposed research strategy as so many individuals will have pre-existing opinions about these treatments. Whilst many complementary therapies may eventually be ‘validated’ by appropriate clinical trial methodologies other research methods could be (...) more appropriate in the early stages of a research strategy, particularly in view of the widespread availability in both the public and private sectors. Safety, efficacy, cost-effectiveness and patient preference also need evaluation; and these cannot be adequately assessed through double blind randomised placebo controlled trials. If the research question is clear, then thoughtful and often innovative evaluative processes can be designed to answer the socially and clinically relevant issues posed by this area of medicine. There are a number of agencies and organizations available to offer advice to ethics committees in this newly emerging field of CAM research including CAM Strategy Research and Development, the Foundation for Integrated Health and the Research Council for Complementary Medicine. (shrink)

The spiritual geography of Russian cosmism. General characteristics ; Recent definitions of cosmism -- Forerunners of Russian cosmism. Vasily Nazarovich Karazin (1773-1842) ; Alexander Nikolaevich Radishchev (1749-1802) ; Poets: Mikhail Vasilyevich Lomonosov, (1711-1765) and Gavriila Romanovich Derzhavin (1743-1816) ; Prince Vladimir Fedorovich Odoevsky (1803-1869) ; Aleksander Vasilyevich Sukhovo-Kobylin (1817-1903) -- The Russian philosophical context. Philosophy as a passion ; The destiny of Russia ; Thought as a call for action ; The totalitarian cast of mind -- The religious and spiritual (...) context. The kingdom of god on earth ; Hesychasm: two great Russian saints ; The Third Rome ; Pre-Christian antecedents -- The Russian esoteric context. Early searches for "deep wisdom" ; Popular magic ; Higher magic in the time of Peter the Great ; Esotericism after Peter the Great ; Theosophy and anthroposophy -- Nikolai Fedorovich Fedorov (1829-1903), the philosopher of the common task ; The one idea ; The unacknowledged prince ; The village teacher ; First disciple: Dostoevsky and Tolstoy ; The Moscow librarian ; Last years: Askhabad: the only portrait -- The "common task" ; Esoteric dimensions of the "common task" ; Fedorov's legacy: projectivism, delo, regulation -- The religious cosmists. Vladimir Sergeevich Solovyov (1853-1900) ; Sergei Nikolaevich Bulgakov (1871-1944) ; Pavel Aleksandrovich Florensky (1882-1937) ; Nikolai Aleksandrovich Berdyaev (1874-1948) -- The scientific cosmists. Konstantin Edouardovich Tsiolkovsky (1857-1935) ; Vladimir Ivanovich Vernadsky (1863-1945) ; Alexander Leonidovich Chizhevsky (1897-1964) ; Vasily Feofilovich Kuprevich (1897-1969) -- Promethean theurgy. Life-creation ; Cultural immortalism ; God-building ; Re-aiming the arrows of Eros ; Technological utopianism ; Occultism -- Fedorov's twentieth century followers. Nikolai Pavlovich Peterson (1844-1919) and Vladimir Aleksandrovich Kozhevnikov (1852-1917) ; Svyatogor and the biocosmists ; New wine and the universal task ; Alexander Konstantinovich Gorsky (1886-1943) and Nikolai Alexandrovich Setnitsky (1888-1937) ; Valerian Nikolaevich Muravyov (1885-1932) ; Vasily Nikolaevich Chekrygin (1897-1922) -- Cosmism and its offshoots today. The N.F. Fedorov museum-library ; The Tsiolkovsky museum and Chizhevsky center ; ISRICA - Institute for Scientific Research in Cosmic Anthropoecology ; Lev Nikolaevich Gumilev (1912-1992) and neo-eurasianism ; The hyperboreans ; Scientific immortalism: Igor Vishev, Danila Medvedev ; Conclusions about the Russian cosmists. (shrink)

The problematics of alienation have played a rather significant role in the discussions\nabout the sense and relevance of Marxism which have taken place in\nthe last twenty years. &dquo;Back to Marx&dquo; was at least one of the main slogans of\nthat ideological/intellectual movement, which evolved both in the East and\nWest from the mid-fifties and which is sometimes referred to as the trend of\n&dquo;humanist&dquo; Marxism. The idea of a &dquo;Marx-Renaissance&dquo; was undoubtedly\ndirected first of all against the completely petrified framework of institutionalized\nMarxism, turned into (...) a &dquo;religion of state&dquo; legitimating the domination\nof a bureaucratic apparatus over the population of East European societies.\nThe &dquo;rediscovery&dquo; and &dquo;rehabilitation&dquo; of the young Marx, the emphasis on\nthe continuity of his thought, meant not only a reintroduction of a number\nof categories, problems and ideas, which were thought fruitful in their critical\ninsight into contemporary conditions and which the impoverished and distorted\nversion of Marxism in official communist ideology (deliberately) failed\nto take into account: it also meant a global challenge to the appropriation of\nthe Marxian tradition by an apologetic ideology, which disguised its positivistic\ncontent through the form of an old-fashioned, dogmatic metaphysics; it\nwas an attempt to recover the critical/emancipatory meaning of this tradition\nwithin the realities of the twentieth century. It was in this context that the\nnotion of &dquo;alienation&dquo; again reappeared -- as a concept through which one\ncould articulate an attitude which was critical simultaneously of Western\ncapitalist and so-called &dquo;socialist&dquo; Eastern societies. Within the framework of\nEast European realities even the rather abstract character of this notion found\nin young Marx, was well suited to the theoretical vagueness and the practical\nlimitations of this new-found leftist criticism of home-societies. (shrink)

Numerous writers have recently called for reform in psychological theorizing and research methodology designed to appreciate the teleological, active agent capacities of humans. This paper presents three studies that probe individual's abilities to volitionally control their eating behavior. These investigations suggest one way that researchers might consider the operation of telic powers in human action. Rather than seeing teleological explanations as rivals to the more traditional causal explanations favored in psychological research, this paper elaborates a position that sees human volition (...) as a causal force embedded in the traditional causal influences studied in psychological research. Finally, the theoretical and methodological refinements suggested here and elsewhere are seen against the backdrop of a philosophy of science that sees change as a more gradual, evolutionary process, rather than the Kuhnian, revolutionary process. (shrink)

Research has established that exposure to a combination of diagnostic (i.e., relevant) and nondiagnostic (i.e., irrelevant) information results in predictions that are more regressive than predictions based on diagnostic information (Hackenbrack, 1992; Hoffman and Patton, 1997). This phenomenon has been labeled the dilution effect (e.g., Tetlock and Boettger, 1989) and has been documented when individuals make predictions. This study tests for the dilution effect when small groups make predictions, and examines the effect of using a procedure designed to reduce the (...) dilution effect. Results indicate that group predictions are influenced by nondiagnostic information in the same manner as are individual predictions, and allowing participants to rate the diagnosticity of information prior to making predictions does not reduce the dilution effect. (shrink)

Research has established that exposure to a combination of diagnostic (i.e., relevant) and nondiagnostic (i.e., irrelevant) information results in predictions that are more regressive than predictions based on diagnostic information (Hackenbrack, 1992; Hoffman and Patton, 1997). This phenomenon has been labeled the dilution effect (e.g., Tetlock and Boettger, 1989) and has been documented when individuals make predictions. This study tests for the dilution effect when small groups make predictions, and examines the effect of using a procedure designed to reduce the (...) dilution effect. Results indicate that group predictions are influenced by nondiagnostic information in the same manner as are individual predictions, and allowing participants to rate the diagnosticity of information prior to making predictions does not reduce the dilution effect. (shrink)

A number of observations have led researchers to postulate that, despite being replication‐defective, human endogenous retroviruses (HERVs) may have retained the potential to cause or contribute to disease. However, mechanisms of HERV pathogenicity might differ substantially from those of modern infectious retroviruses or of the infectious precursors of HERVs. Therefore, novel pathways of HERV involvement in disease pathogenesis should be investigated. Recent technological advances in sequencing and bioinformatics are making this task increasingly feasible. The accumulating knowledge of HERV biology may (...) also facilitate the definition and general acceptance of criteria that establish HERV pathogenicity. Here, we explore possible mechanisms whereby HERVs may cause disease and examine the evidence that either has been or should be obtained in order to decisively address the pathogenic potential of HERVs. (shrink)

This collection of essays on themes in the work of John Locke , George Berkeley , and David Hume , provides a deepened understanding of major issues raised in the Empiricist tradition. In exploring their shared belief in the experiential nature of mental constructs, The Empiricists illuminates the different methodologies of these great Enlightenment philosophers and introduces students to important metaphysical and epistemological issues including the theory of ideas, personal identity, and skepticism. It will be especially useful in courses (...) devoted to the history of modern philosophy. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

Working memory deficits are pervasive co-morbidities of epilepsy. Although the pathophysiological mechanisms underpinning these impairments remain elusive, it is thought that WM depends on oscillatory interactions within and between nodes of large-scale functional networks. These include the hippocampus and default mode network as well as the prefrontal cortex and frontoparietal central executive network. Here, we review the functional roles of neural oscillations in subserving WM and the putative mechanisms by which epilepsy disrupts normative activity, leading to aberrant oscillatory signatures. We (...) highlight the particular role of interictal epileptic activity, including interictal epileptiform discharges and high frequency oscillations in WM deficits. We also discuss the translational opportunities presented by greater understanding of the oscillatory basis of WM function and dysfunction in epilepsy, including potential targets for neuromodulation. (shrink)

This chapter contains section titled: Life and Works Theory of Vision Abstract Ideas Matter Does Not Exist Spirits and Ideas Exist Physics Mathematics Language Berkeley's Later Philosophy Philosophical Legacy Author's Note.

"If we are to understand not only the direct impact of Marx on the development of German thought but also his sometimes extremely indirect influence, an exact knowledge of Hegel, of both his greatness and his limitation, is absolutely indispensable."- from the preface. It is well known that Hegel exerted a major influence on the development of Marx's thought. This circumstance led Lukács, one of the chief Marxist theoreticians of this century, to embark on his exploration of Hegelian antecedents in (...) the German intellectual tradition, their concrete expression in the work of Hegel himself, and later syntheses of seemingly contradictory modes of though. Four phases of Hegel's intellectual development are examined: "Hegel's early republican phase," "the crisis in Hegel's views on society and the earliest beginnings of his dialectical method," "rationale and defense of objective idealism," and "the breach with Schelling and The Phenomenology of Mind." Lukács completed this study in 1938, but because of the imminent outbreak of war, it was not published until the late 1940s. A revised German edition appeared in 1954, and it is this text that is the basis of this first English translation of the work. (shrink)

In one study funded by the United States Department of Agriculture, people from North Dakota were interviewed to discover which moral principles they use in evaluating the morality of transgenic organisms and their introduction into markets. It was found that although the moral codes the human subjects employed were very similar, their views on transgenics were vastly different. In this paper, the codes that were used by the respondents are developed, compared to that of the academically composed Belmont Report, and (...) then modified to create the more practical Common Moral Code. At the end, it is shown that the Common Moral Code has inherent inconsistency flaws that might be resolvable, but would require extensive work on the definition of terms and principles. However, the effort is worthwhile, especially if it results in a common moral code that all those involved in the debate are willing to use in negotiating a resolution to their differences. (shrink)

This book presents the first English translation of the original French treatise “La Physique d’Einstein” written by the young Georges Lemaître in 1922, only six years after the publication of Albert Einstein’s theory of General Relativity. It includes an historical introduction and a critical edition of the original treatise in French supplemented by the author’s own later additions and corrections. -/- Monsignor Georges Lemaître can be considered the founder of the “Big Bang Theory” and a visionary architect of modern (...) Cosmology. The scientific community is only beginning to grasp the full extent of the legacy of this towering figure of 20th century physics. Against the best advice of the greatest names of his time, the young Lemaître was convinced, solely through the study of Einstein’s theory of General Relativity, that space and time must have had a beginning with a tremendous “Big Bang” from a “quantum primeval atom” resulting in an ever-expanding Universe with a positive cosmological constant. -/- But how did the young Lemaître, essentially on his own, come to grips with the physics of Einstein? A year before his ordination as a diocesan priest, he submitted the audacious treatise, published in this book, that was to earn him Fellowships to study at Cambridge, MIT and Harvard, and launched him on a scientific path of ground-breaking discoveries. Almost a century after Lemaître’s seminal publications of 1927 and 1931, this highly pedagogical treatise is still of timely interest to young minds and remains of great value from a history of science perspective. (shrink)

How did I come to non-reductive neurophilosophy? Let me sketch my biography a little. When I was young, I always wanted to study philosophy, the basic questions of the world, humans and the mind fascinated me – going down to the bottom of things. However, I did not want to study philosophy in isolation from the science. My fascination was and still is on the mind and specifically subjectivity as core feature of the mind. Subjectivity and mind are obviously (...) key topics in philosophy. However, having grown up from the mid/end of the 20 th century allowed me to also study the mind empirically and thus to complement philosophy by science. At my time there were no neuroscience programs yet. Hence, the only way to study the brain and its connection to the mind was to go into medicine which I did parallel to my philosophy studies. ER -. (shrink)

We question whether Plamondon & Alimi's model is useful in accounting for the nonsymmetrical and multiple-peaked velocity profiles observed in young and elderly subjects for ballistic aiming tasks. For these subjects, both data and observation suggest that a central representation initiates the movement in an appropriate direction but that multiple adjustments are made, both early and late, to achieve spatial accuracy.

Multiculturalism is one of the most controversial ideas in contemporary politics. In this new book George Crowder examines some of the leading responses to multiculturalism, both supportive and critical, found in the work of recent political theorists. The book provides a clear and accessible introduction to a diverse array of thinkers who have engaged with multiculturalism. These include Will Kymlicka, whose account of cultural rights is seminal, liberal critics of multiculturalism such as Brian Barry and Susan Okin, and multiculturalist (...) critics of liberalism including Charles Taylor, Iris Marion Young, James Tully, and Bhikhu Parekh. In addition the discussion covers a wide range of other perspectives on multiculturalism - libertarian, feminist, democratic, nationalist, cosmopolitan - and rival accounts of Islamic and Confucian political culture. While offering a balanced assessment of these theories, Crowder also argues the case for a distinctive liberal-pluralist approach to multiculturalism, combining a liberal framework that emphasises the importance of personal autonomy with the value pluralism of thinkers such as Isaiah Berlin. This clear and comprehensive account will be an indispensable textbook for students in politics, sociology and political and social theory. (shrink)

George Faithful tells the story of a group of young Lutheran women who formed the Ecumenical Sisterhood of Mary in 1947 in order to advocate collective national guilt for the sins of the German people (Volk) against God and against the Jews.

It is not too great an exaggeration to claim that On the Origin of Species was, along with Das Kapital, one of the two most significant works in the intellectual history of the nineteenth century. As George Henry Lewes wrote in 1868, ‘No work of our time has been so general in its influence’. However, the very generality of the influence of Darwin’s work provides the chief problem for the intellectual historian. Most books and articles on the subject assert (...) the influence but remain very imprecise about its nature. It is very difficult indeed to assess what it was about the Darwinian theory which was so influential and how its influence was felt. This problem in Victorian intellectual history intersects with a related one in the history of science. There has been a tendency on the part of historians of science to isolate Darwin in two related ways. The first is to single him out from the mainstream of nineteenth-century naturalism in Britain and allow ‘Darwinism’ to stand duty for the wider movement of which it was in fact but a part. The second is the tendency to single out his evolutionary theory and to demarcate it sharply from those of his predecessors and contemporaries. According to this interpretation Darwin stood alone as a real, empirical scientist and provided the first genuinely scientific hypothesis for the process by which evolution might have occurred. The theories of the other main evolutionists—Erasmus Darwin, Lamarck, Chambers, Spencer, and Wallace—were more or less besmirched by ideological, anthropomorphic, or other ‘non-scientific’ factors or by the uses to which they were put by their authors. Charles Darwin is thus made to stand out as a figure of comparatively unalloyed scientific status and is treated in relative isolation from the social and intellectual context in which he worked and into which his theory was received. (shrink)

George Herbert Mead, one of America’s most important and influential philosophers, a founder of pragmatism, social psychology, and symbolic interactionism, was also a keen observer of American culture and early modernism. In the period from the 1870s to 1895, Henry Northrup Castle maintained a correspondence with family members and with Mead—his best friend at Oberlin College and brother-in-law—that reveals many of the intellectual, economic, and cultural forces that shaped American thought in that complex era. Close friends of John Dewey, (...) Jane Addams, and other leading Chicago Progressives, the author of these often intimate letters comments frankly on pivotal events affecting higher education, developments at Oberlin College, Hawaii, progressivism, and the general angst that many young intellectuals were experiencing in early modern America. The letters, drawn from the Mead-Castle collection at the University of Chicago, were collected and edited by Mead after the tragic death of Henry Castle in a shipping accident in the North Sea. Working with his wife Helen Castle, he privately published fifty copies of the letters to record an important relationship and as an intellectual history of two progressive thinkers at the end of the nineteenth century. American historians, such as Robert Crunden and Gary Cook, have noted the importance of the letters to historians of the late nineteenth century. The letters are made available here using the basic Mead text of 1902. Additional insights into the connection between Mead, John Dewey, Henry and Harriet Castle, and Hawaii’s progressive kindergarten system are provided by the foundation’s executive director Alfred L. Castle. Marvin Krislov, president of Oberlin College, has added additional comments on the importance of the letters to understanding the intellectual relationship that flourished at Oberlin College. Published with the support of the Samuel N. and Mary Castle Foundation. (shrink)

Fourfold is thought to be a defining theme of Heidegger’s later thought, and yet it remains to be one of the most controversial notions in Heidegger scholarship. Interpreting the fourfold has been a challenging issue. Some of them dismissed it as having no real philosophical weight, despite its overarching presence in many of Heidegger’s later literature. Some of them tried to interpret it without giving due attention to the intricacies at hand. In this paper, we argue that, Julian Young’s (...) understanding of the fourfold in terms of the twofold of nature and culture has certain drawbacks owing to its emphasis on the literal meanings. We also suggest an interpretative strategy to avoid the pitfalls of literal and metaphorical readings, in which Andrew Mitchell’s interpretation is a good case in point. Mitchell’s marvelous attempt to think the fourfold in terms of relationality, can be seen as a best ever effort, in that, it not only remedies many of the problems of previous interpretations, including that of Young but it also gives due consideration to the intricate relations between what Heidegger would call the technological standing reserve and the thing of the fourfold. We will also discuss how Young’s interpretative problems can be remedied, in the new light provided by Mitchell. Finally, we suggest that Mitchell’s reading should be complemented with an adequate account of the holy, in which, the holy is understood as a principle of unification and wholesomeness of the members of the fourfold, apart from understanding it purely in terms of the God, one of the members of the fourfold. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews 133 Beyond the Outer Shores: The Untold Odyssey of Ed Ricketts, the Pioneering Ecologist Who Inspired John Steinbeck and Joseph Campbell BY ERIC ENNO TAMM New York: Thunder’s Mouth Press, 2004 REVIEWED BY GEORGE MEADOWS How do you write a biography of someone who is best known as a fictional character? This is the challenge Erik Tamm has taken on in his recent biography of Edward (...) Ricketts, Beyond the Outer Shores. While some may know Ricketts as a pioneering ecologist and the author of the classic marine biology text, Between Pacific Tides, most know him as the model for “Doc” in the popular John Steinbeck novel Cannery Row, and the eponymous film adaptation. Much of the challenge arises from the fact that the fictional Doc as portrayed in Cannery Row is one of the most endearing characters in Steinbeck’s works. And according to all sources, Ed Ricketts shared many of Doc’s best qualities, and many of the incidents, people, and places in the novel are based on things Ed did and the people he knew. I would guess that many would be satisfied with knowing Ed Ricketts as Doc. It’s very tempting to do just that. The Monterey Peninsula, the location for the novel, is a beautiful place and it’s hard not to sense the presence of both Doc and Ed there. You might see them in Rickett’s restored laboratory/home, just a few feet from the entrance to the Monterey Bay Aquarium, or in the bronze statue of Ricketts placed near the site of his untimely death at the age of fifty-­ one. There’s also a Steinbeck monument in Steinbeck Plaza depicting the writer, Ed Ricketts, and several figures who play important roles in Cannery Row. The tide pools, which play such an important role in both Ed and Doc’s work are nearby and easily accessible. As a reader (and re-­reader) of Cannery Row and a frequent visitor to the Monterey Peninsula, I find it tempting to let Ed be Doc. To do so though would largely ignore the role he played in the development of ecology. Tamm’s book does focus on these achievements, and it does so in a way that would make sense to an ecologist: examining place and the ENVIRONMENT, SPACE, PLACE / VOLUME 13 / ISSUE 2 / 2021 134 relationships among individuals as they are influenced by that place. Thus, we have chapters titled “The Lab,” “The Great Tide Pool,” and “Clayoquot, Stubbs Island.” Other chapters deal with collecting trips to the Gulf of California and Juneau, Alaska. Each of these chapters provides a great deal of information about Ricketts’s ecological work in the area but also discuss his personal relationships as they developed in that space. This makes for interesting reading when we consider that these relationships involved such people as John Steinbeck, Henry Miller, and Joseph Campbell. The best example of this comes during the description of Ricketts’s 1932 collecting trip to Juneau with a young Campbell. The pair spent three months observing and collecting samples of marine life from the coastal areas. They also engaged in a number of discussions integrating ecology, biology, mythology, and religion. The discussion would continue for some time after, largely by mail, and their relationship takes up again in the final chapters of the book. While this approach does provide much of value, it can also make for a challenging read. The linear sequence that we might expect in a biography is somewhat absent in this book, to the degree that other reviewers describe the book as “nonlinear and disorganized,” or “confusing in sequence.” The focus on place and relationships, central to ecology, is difficult to mesh with the focus on an individual that we expect in biography, and this can be a difficult conflict to resolve. Individual organisms might be interesting, but that interest arises from the organism’s physical and social place. Ed Ricketts as an individual is not all that important. Our understanding of Ed should derive from his presence in certain locations and the relationships he had in those places. Or, as Michael Lannoo notes in Leopold’s Shack and Ricketts... (shrink)